Endocrine Abstracts

Moderately elevated plasma homocysteine levels (>12 μmol/l) are highly prevalent in the general population and are associated with an increased risk for cardiovascular disease. Homocysteine is an amino acid produced during catabolism of the essential amino acid methionine. Metabolism of homocysteine requires an adequate supply of folic acid, vitamin B12 and vitamin B6.Moderate hyperhomocysteinemia may be caused by a variety of factors: chronic d...

Introduction: In normal subjects GH is a hyperglycemic hormone as opposed to insulin-like growth factor 1 (IGF1). Active acromegaly is associated with insulin resistance (IR) and glucose intolerance although both GH and IGF1 are elevated. Our objective was to assess whether GH, IGF1 or both are risk factors for IR and glucose intolerance in acromegaly.Methods: Basal serum IGF1 and GH, glucose and insulin during an oral glucose tolerance test were measure...